Frédéric Grouiller

Function: Adjoint scientifique

Group name: Innovative Clinical Multimodal Brain Imaging

Affiliations: Department of Basic Neurosciences

Keywords: attention regulation, brain imaging, Magnetic resonance imaging, multimodal imaging, Neurofeedback, virtual reality

Research activities

Our multidisciplinary research group is dedicated to advancing the field of multimodal imaging techniques for clinical applications. Our primary focus is to combine Magnetic Resonance Imaging (MRI) at 3 or 7T with other non-invasive tools to deepen our understanding of brain functions. By integrating these modalities, we strive to enhance the clinical workflow and improve the quality of life for patients. Our translational research is centered around three key areas:

– EEG/fMRI: development of novel tools to enable the integration of simultaneous EEG and fMRI, particularly in real-time applications such as bimodal neurofeedback. Our goal is to leverage this technology to help patients with attention deficits or epilepsy, facilitating targeted interventions and personalized treatment approaches.

– Virtual Reality (VR): combination of VR with MRI to explore alternative solutions to medication for children. Specifically, we seek to employ VR to assist children with attention deficit in regulating their attention and preparing them for MRI examinations without the need for anaesthesia.

– Quantitative functional brain mapping: development of new imaging techniques based on MRI perfusion to obtain quantitative mapping of functional brain functions. We aim to optimize patient outcomes by enhancing our ability to accurately delineate critical brain regions for surgical planning.

Funding: SNSF grant

Key publications

The relationship between EEG and fMRI connectomes is reproducible across simultaneous EEG-fMRI studies from 1.5T to 7T.

Wirsich J, Jorge J, Iannotti GR, Shamshiri EA, Grouiller F, Abreu R, Lazeyras F, Giraud AL, Gruetter R, Sadaghiani S, Vulliémoz S.

Neuroimage - 2021 May 1;231:117864

Modulation of epileptic networks by transient interictal epileptic activity: A dynamic approach to simultaneous EEG-fMRI.

Iannotti GR, Preti MG, Grouiller F, Carboni M, De Stefano P, Pittau F, Momjian S, Carmichael D, Centeno M, Seeck M, Korff CM, Schaller K, De Ville DV, Vulliemoz S.

Neuroimage Clin. 2020;28:102467.

Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results.

Grouiller F, Jorge J, Pittau F, van der Zwaag W, Iannotti GR, Michel CM, Vulliémoz S, Vargas MI, Lazeyras F.

MAGMA. 2016 Jun;29(3):605-16.

Towards high-quality simultaneous EEG-fMRI at 7T: Detection and reduction of EEG artifacts due to head motion.

Jorge J, Grouiller F, Gruetter R, van der Zwaag W, Figueiredo P.

Neuroimage. 2015 Oct 15;120:143-53

All-in-one interictal presurgical imaging in patients with epilepsy: single-session EEG/PET/(f)MRI.

Grouiller F, Delattre BM, Pittau F, Heinzer S, Lazeyras F, Spinelli L, Iannotti GR, Seeck M, Ratib O, Vargas MI, Garibotto V, Vulliemoz S.

Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1133-43

See the complete list of the publications

Contact

Faculté de médecine
Université de Genève
Email: Frederic.Grouiller@unige.ch