Yvan Gasche

Group name: Ischemic Brain Injury

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Anaesthetics, Pharmacology and Intensive Care

Domains: Development and Plasticity

Keywords: blood-brain barrier, cerebral ischemia, neuronal degeneration, stroke

Research activities

The laboratory is interested in the molecular mechanisms involved in blood-brain barrier disruption and neuronal degeneration in ischemic brain injury. Brain edema and hemorrhagic transformation are the main cause of early mortality in ischemic stroke patients. Gelatinase B, an inducible matrix metalloproteinase overexpressed during cerebral ischemia, is associated to the proteolysis of the basal lamina resulting in blood-brain barrier disruption, brain edema and cerebral hemorrhage after stroke. We currently explore different therapeutic strategies focused on the role of gelatinase B to reduce the risk of hemorrhage and brain edema both in animal models of embolic stroke and in patients. We also investigate the mechanisms of ischemic brain injury in patients following cardiac arrest and in patients developing delayed ischemic injury due to vasospasm after subarachnoid hemorrhage.

Latest publications

Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C.

Stammet P , Dankiewicz J , Nielsen N , Fays F , Collignon O , Hassager C , Wanscher M , Undèn J , Wetterslev J , Pellis T , Aneman A , Hovdenes J , Wise MP , Gilson G , Erlinge D , Horn J , Cronberg T , Kuiper M , Kjaergaard J , Gasche Y , Devaux Y , Friberg H ,

Critical care (London, England) - Jun 2017

Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest - A TTM-Trial Substudy.

Wiberg S , Hassager C , Stammet P , Winther-Jensen M , Thomsen JH , Erlinge D , Wanscher M , Nielsen N , Pellis T , Åneman A , Friberg H , Hovdenes J , Horn J , Wetterslev J , Bro-Jeppesen J , Wise MP , Kuiper M , Cronberg T , Gasche Y , Devaux Y , Kjaergaard J

PloS one - 2017

Infectious complications after out-of-hospital cardiac arrest-A comparison between two target temperatures.

Dankiewicz J , Nielsen N , Linder A , Kuiper M , Wise MP , Cronberg T , Erlinge D , Gasche Y , Harmon MB , Hassager C , Horn J , Kjaergaard J , Pellis T , Stammet P , Undén J , Wanscher M , Wetterslev J , Åneman A , Ullén S , Juffermans NP , Friberg H ,

Resuscitation - Apr 2017

Life-threatening neuroleptic withdrawal emergent syndrome resembling status dystonicus.

Pugin D , Bally J , Horvath J , Pollak P , Gasche Y , Burkhard PR

Parkinsonism & related disorders - Feb 2017

See the complete list of the publications

Videos

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Contact

Département d’Anesthésiologie, Pharmacologie et Soins Intensifs
HUG
Email: Yvan.Gasche@unige.ch