Our research group works on molecular neuroimaging, a tool allowing the in vivo measurement of protein deposits, brain metabolism and neurotransmission. Molecular imaging has changed the way we understand brain disorders, especially those associated with neurodegeneration. In this field, the current gold standard is still neuropathology at post-mortem: this represents an intrinsic limitation for the development and assessment of targeted therapies. The availability of in vivo biomarkers of the disease, among these molecular imaging, finally offers an opportunity for precision medicine in degenerative disorders and has already changed how we evaluate patients and how we test new drugs. Our group benefits from a unique and privileged position, on one hand working in close collaboration with various research groups at the Geneva University and abroad and on the other hand being embedded in a clinical division of the Geneva University Hospitals for patient diagnosis and care. This position allows us to translate new ideas and knowledge, coming from basic and applied research programs, into procedures that can be tested in clinical studies and validated for clinical practice.
PET Imaging in Neurodegeneration and Neuro-oncology: Variants and Pitfalls.
Clinical validity of increased cortical binding of tau ligands of the THK family and PBB3 on PET as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework.
The strategic biomarker roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update.
Molecular imaging and fluid biomarkers of Alzheimer's disease neuropathology: an opportunity for integrated diagnostics.
Département de radiologie et informatique médicale
Faculty of Medicine
Service de Médecine nucléaire et imagerie moléculaire, Département diagnostique