Philippe Millet

Function: Professeur associé

Group name: PET and SPECT Quantification

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Psychiatry

Keywords: neuroimaging, PET/SPECT, radioligand

Research activities

Our research projects focus on various themes of neuroimaging including the development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems and neuroinflammation using various PET/SPECT TSPO tracers. We are interested in preclinical PET/SPECT applications and the mechanism of action of atypical antipsychotics. We also study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer’s disease. In vitro studies on the post-mortem human brain are also performed in ou lab for the identification and characterization of inflammation with respect to neurodegenerative pathologies. We are also interested in the clinical application of the neuroinflammatory process in various psychiatric pathologies

Latest publications

18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity.

Tournier BB , Bouteldja F , Amossé Q , Nicolaides A , Duarte Azevedo M , Tenenbaum L , Garibotto V , Ceyzériat K , Millet P

ACS omega - Aug 2023

Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA?

Veraldi N , Quadri ID , van de Looij Y , Modernell LM , Sinquin C , Zykwinska A , Tournier BB , Dalonneau F , Li H , Li JP , Millet P , Vives R , Colliec-Jouault S , de Agostini A , Sanches EF , Sizonenko SV

Carbohydrate polymers - Nov 2023

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Nutma E , Fancy N , Weinert M , Tsartsalis S , Marzin MC , Muirhead RCJ , Falk I , Breur M , de Bruin J , Hollaus D , Pieterman R , Anink J , Story D , Chandran S , Tang J , Trolese MC , Saito T , Saido TC , Wiltshire KH , Beltran-Lobo P , Phillips A , Antel J , Healy L , Dorion MF , Galloway DA , Benoit RY , Amossé Q , Ceyzériat K , Badina AM , Kövari E , Bendotti C , Aronica E , Radulescu CI , Wong JH , Barron AM , Smith AM , Barnes SJ , Hampton DW , van der Valk P , Jacobson S , Howell OW , Baker D , Kipp M , Kaddatz H , Tournier BB , Millet P , Matthews PM , Moore CS , Amor S , Owen DR

Nature communications - Aug 2023

Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.

Ceyzériat K , Nicolaides A , Amossé Q , Fossey C , Cailly T , Fabis F , Garibotto V , Escartin C , Tournier BB , Millet P

Molecular brain - Jul 2023

See the complete list of the publications

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Contact

Département de psychiatrie
HUG
Email: Philippe.Millet@hcuge.ch