Philippe Millet
Function: Professeur associé
Group name: PET and SPECT Quantification
Group type: Main
Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Psychiatry
Domains: Development and Plasticity
Keywords: neuroimaging, PET/SPECT, radioligand
Research activities
Our research projects focus on various themes of neuroimaging including the development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems and neuroinflammation using various PET/SPECT TSPO tracers. We are interested in preclinical PET/SPECT applications and the mechanism of action of atypical antipsychotics. We also study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer’s disease. In vitro studies on the post-mortem human brain are also performed in ou lab for the identification and characterization of inflammation with respect to neurodegenerative pathologies. We are also interested in the clinical application of the neuroinflammatory process in various psychiatric pathologies
Latest publications
Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease.
Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease.
Low-Dose Radiation Therapy Impacts Microglial Inflammatory Response without Modulating Amyloid Load in Female TgF344-AD Rats.
A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization.
Contact
Département de psychiatrie
HUG
Email: Philippe.Millet@hcuge.ch