Function: Professeur associé
Group name: PET and SPECT Quantification
Group type: Main
Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Psychiatry
Domains: Development and Plasticity
Keywords: neuroimaging, PET/SPECT, radioligand
Our research projects focus on various themes of neuroimaging including the development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems and neuroinflammation using various PET/SPECT TSPO tracers. We are interested in preclinical PET/SPECT applications and the mechanism of action of atypical antipsychotics. We also study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer’s disease. In vitro studies on the post-mortem human brain are also performed in ou lab for the identification and characterization of inflammation with respect to neurodegenerative pathologies. We are also interested in the clinical application of the neuroinflammatory process in various psychiatric pathologies
The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects.
Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats.
Low-Dose Radiation Therapy Reduces Amyloid Load in Young 3xTg-AD Mice.
Dopamine and Neuroinflammation in Schizophrenia - Interpreting the Findings from Translocator Protein (18kDa) PET Imaging.
Département de psychiatrie