Our research projects focus on various themes of neuroimaging including the development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems and neuroinflammation using various PET/SPECT TSPO tracers. We are interested in preclinical PET/SPECT applications and the mechanism of action of atypical antipsychotics. We also study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer’s disease. In vitro studies on the post-mortem human brain are also performed in ou lab for the identification and characterization of inflammation with respect to neurodegenerative pathologies. We are also interested in the clinical application of the neuroinflammatory process in various psychiatric pathologies
18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity.
Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA?
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.
Département de psychiatrie