Our research projects focus on various themes of neuroimaging including the development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems and neuroinflammation using various PET/SPECT TSPO tracers. We are interested in preclinical PET/SPECT applications and the mechanism of action of atypical antipsychotics. We also study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer’s disease. In vitro studies on the post-mortem human brain are also performed in ou lab for the identification and characterization of inflammation with respect to neurodegenerative pathologies. We are also interested in the clinical application of the neuroinflammatory process in various psychiatric pathologies
Treatment by low-dose brain radiation therapy improves memory performances without changes of the amyloid load in the TgF344-AD rat model.
Effect of 5-HT2A receptor antagonism on levels of D2/3 receptor occupancy and adverse behavioral side-effects induced by haloperidol: a SPECT imaging study in the rat.
Cellular sources of TSPO expression in healthy and diseased brain.
Dopamine D2/3 Receptor Availabilities and Evoked Dopamine Release in Striatum Differentially Predict Impulsivity and Novelty Preference in Roman High- and Low-Avoidance Rats.
Département de psychiatrie