Philippe Millet
Function: Professeur associé
Group name: PET and SPECT Quantification
Group type: Main
Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Psychiatry
Domains: Development and Plasticity
Keywords: neuroimaging, PET/SPECT, radioligand
Research activities
Our research projects focus on various themes of neuroimaging including the development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems and neuroinflammation using various PET/SPECT TSPO tracers. We are interested in preclinical PET/SPECT applications and the mechanism of action of atypical antipsychotics. We also study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer’s disease. In vitro studies on the post-mortem human brain are also performed in ou lab for the identification and characterization of inflammation with respect to neurodegenerative pathologies. We are also interested in the clinical application of the neuroinflammatory process in various psychiatric pathologies
Latest publications
Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer's disease.
Radiation dosimetry of the 18 kDa translocator protein ligand [F]PBR111 in humans.
Stools from a human APOEe2 donor reduces amyloid and tau pathology and increases neuroinflammation in a 3xTg AD mouse model.
Brain and plasmatic CLUSTERIN are translational markers of Alzheimer's disease.
Contact
Département de psychiatrie
HUG
Email: Philippe.Millet@hcuge.ch