Philippe Millet

Function: Professeur associé

Group name: PET and SPECT Quantification

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Psychiatry

Keywords: neuroimaging, PET/SPECT, radioligand

Research activities

Our research projects focus on various themes of neuroimaging including the development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems and neuroinflammation using various PET/SPECT TSPO tracers. We are interested in preclinical PET/SPECT applications and the mechanism of action of atypical antipsychotics. We also study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer’s disease. In vitro studies on the post-mortem human brain are also performed in ou lab for the identification and characterization of inflammation with respect to neurodegenerative pathologies. We are also interested in the clinical application of the neuroinflammatory process in various psychiatric pathologies

Latest publications

Stools from a human APOEe2 donor reduces amyloid and tau pathology and increases neuroinflammation in a 3xTg AD mouse model.

Marizzoni M , Tournier BB , Chevalier C , Saleri S , Lathuilière A , Ceyzériat K , Paquis A , Park R , Troesch E , Cattaneo A , Millet P , Frisoni GB

Frontiers in aging neuroscience - 2025

Brain and plasmatic CLUSTERIN are translational markers of Alzheimer's disease.

Tournier BB , Ceyzériat K , Marteyn A , Amossé Q , Badina AM , Tsartsalis S , Herrmann FR , Zekry D , Millet P

Brain pathology (Zurich, Switzerland) - Mar 2025

Early metabolic changes in the brain of Alzheimer's disease rats are driven by GLAST+ cells.

Morrey WJ , Ceyzériat K , Amossé Q , Badina AM , Dickie B , Schiessl I , Tsartsalis S , Millet P , Boutin H , Tournier BB

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - Feb 2025

Fecal Microbiota Transplantation (FMT) From a Human at Low Risk for Alzheimer's Disease Improves Short-Term Recognition Memory and Increases Neuroinflammation in a 3xTg AD Mouse Model.

Chevalier C , Tournier BB , Marizzoni M , Park R , Paquis A , Ceyzériat K , Badina AM , Lathuiliere A , Saleri S , Cillis F , Cattaneo A , Millet P , Frisoni GB

Genes, brain, and behavior - Feb 2025

See the complete list of the publications

Contact

Département de psychiatrie
HUG
Email: Philippe.Millet@hcuge.ch