Philippe Bijlenga

Philippe Bijlenga

Group name: Cerebral Ischemia

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domains: Development and Plasticity

Keywords: calcium signaling, cerebral ischemia, stroke

Research activities

The interest of the laboratory is focused on stroke. Cerebral ischemia induces a significant early and sustained increase of the intracellular calcium concentration. It also has been observed that an increase of intracellular calcium lasting long enough could trigger delayed neuronal death. Preventing the intracellular calcium increase during an ischemic insult by reducing the extracellular calcium concentration prevents delayed neuronal death. The research in the laboratory is therefore focused on understanding the alteration of intracellular calcium signaling during an ischemic insult. The effort is currently concentrated on understanding the implication of a specific type of voltage-activated calcium channel present on the plasma membrane during ischemia. Neuronal ischemia is studied on three different models. Electrophysiology and calcium imaging is performed on dissociated neuronal cultures during ischemic insults. Pharamacology and neuroprotection studies are performed first in an in vitro model with organotypic hippocampal slice cultures and then in an in vivo model of global ischemia in rats.

Latest publications

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis.

Morel S , Hostettler IC , Spinner GR , Bourcier R , Pera J , Meling TR , Alg VS , Houlden H , Bakker MK , Van't Hof F , Rinkel GJE , Foroud T , Lai D , Moomaw CJ , Worrall BB , Caroff J , Constant-Dits-Beaufils P , Karakachoff M , Rimbert A , Rouchaud A , Gaal-Paavola EI , Kaukovalta H , Kivisaari R , Laakso A , Jahromi BR , Tulamo R , Friedrich CM , Dauvillier J , Hirsch S , Isidor N , Kulcsàr Z , Lövblad KO , Martin O , Machi P , Mendes Pereira V , Rüfenacht D , Schaller K , Schilling S , Slowik A , Jaaskelainen JE , von Und Zu Fraunberg M , Jiménez-Conde J , Cuadrado-Godia E , Soriano-Tárraga C , Millwood IY , Walters RG , The neurIST Project , The Ican Study Group , Genetics And Observational Subarachnoid Haemorrhage Gosh Study Investigators , International Stroke Genetics Consortium Isgc , Kim H , Redon R , Ko NU , Rouleau GA , Lindgren A , Niemelä M , Desal H , Woo D , Broderick JP , Werring DJ , Ruigrok YM , Bijlenga P
Journal of personalized medicine - Aug 2022
See the complete list of the publications



Departement des neurosciences cliniques