Philippe Bijlenga

Philippe Bijlenga

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Group name: Cerebral Ischemia

Domains: Development and Plasticity

Keywords: calcium signaling, cerebral ischemia, stroke

Research activities

The interest of the laboratory is focused on stroke. Cerebral ischemia induces a significant early and sustained increase of the intracellular calcium concentration. It also has been observed that an increase of intracellular calcium lasting long enough could trigger delayed neuronal death. Preventing the intracellular calcium increase during an ischemic insult by reducing the extracellular calcium concentration prevents delayed neuronal death. The research in the laboratory is therefore focused on understanding the alteration of intracellular calcium signaling during an ischemic insult. The effort is currently concentrated on understanding the implication of a specific type of voltage-activated calcium channel present on the plasma membrane during ischemia. Neuronal ischemia is studied on three different models. Electrophysiology and calcium imaging is performed on dissociated neuronal cultures during ischemic insults. Pharamacology and neuroprotection studies are performed first in an in vitro model with organotypic hippocampal slice cultures and then in an in vivo model of global ischemia in rats.

Latest publications

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.

Bakker MK , van der Spek RAA , van Rheenen W , Morel S , Bourcier R , Hostettler IC , Alg VS , van Eijk KR , Koido M , Akiyama M , Terao C , Matsuda K , Walters RG , Lin K , Li L , Millwood IY , Chen Z , Rouleau GA , Zhou S , Rannikmäe K , Sudlow CLM , Houlden H , van den Berg LH , Dina C , Naggara O , Gentric JC , Shotar E , Eugène F , Desal H , Winsvold BS , Børte S , Johnsen MB , Brumpton BM , Sandvei MS , Willer CJ , Hveem K , Zwart JA , Verschuren WMM , Friedrich CM , Hirsch S , Schilling S , Dauvillier J , Martin O , , , , , , , , Jones GT , Bown MJ , Ko NU , Kim H , Coleman JRI , Breen G , Zaroff JG , Klijn CJM , Malik R , Dichgans M , Sargurupremraj M , Tatlisumak T , Amouyel P , Debette S , Rinkel GJE , Worrall BB , Pera J , Slowik A , Gaál-Paavola EI , Niemelä M , Jääskeläinen JE , von Und Zu Fraunberg M , Lindgren A , Broderick JP , Werring DJ , Woo D , Redon R , Bijlenga P , Kamatani Y , Veldink JH , Ruigrok YM
Nature genetics - Dec 2020
See the complete list of the publications



Departement des neurosciences cliniques