Patrice Lalive
Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences
Group name: Neuroimmunology
Domains: Development and Plasticity, Sensory and Motor Systems
Keywords: biomarkers, encephalitis, multiple sclerosis, neurodegeneration, neuroprotection
Research activities
Our group is interested in both fundamental and clinically-oriented research projects in inflammatory/demyelinating diseases of the central nervous system (CNS), and in particular on the pathogenesis and regulation of Multiple Sclerosis (MS). Our major interests are (i) the search for new biomarkers for MS inflammation and neurodegeneration and (ii) the identification of the mechanisms of action of current MS therapies.
Because of its many similarities to MS, experimental autoimmune encephalitis (EAE), the animal model of MS, is regularly used in our laboratory to study MS pathogenesis and regulation. We are currently developing new animal models to study the neuroprotective effects of HGF separate from its immune-regulating properties.
The major research topics of our group are: Multiple Sclerosis and demyelinating diseases of the CNS ; Experimental Autoimmune Encephalitis ; Biomarkers of the serum and the cerebrospinal fluid in MS ; Study of neuroprotective factors in EAE and MS ; Study of Human Herpes-6 variant A and B in sporadic encephalitis.
Latest publications
Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis.
CD4c-MetItgα4 T cell subset promotes murine neuroinflammation.
Functional connectivity underlying cognitive and psychiatric symptoms in post-COVID-19 syndrome: is anosognosia a key determinant?
Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.
Contact
Département des neurosciences cliniques
HUG
Email: Patrice.Lalive@hcuge.ch