Patrice Lalive

Function: Professeur associé

Group name: Neuroimmunology

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domains: Development and Plasticity, Sensory and Motor Systems

Keywords: biomarkers, encephalitis, multiple sclerosis, neurodegeneration, neuroprotection

Research activities

Our group is interested in both fundamental and clinically-oriented research projects in inflammatory/demyelinating diseases of the central nervous system (CNS), and in particular on the pathogenesis and regulation of Multiple Sclerosis (MS). Our major interests are (i) the search for new biomarkers for MS inflammation and neurodegeneration and (ii) the identification of the mechanisms of action of current MS therapies.
Because of its many similarities to MS, experimental autoimmune encephalitis (EAE), the animal model of MS, is regularly used in our laboratory to study MS pathogenesis and regulation. We are currently developing new animal models to study the neuroprotective effects of HGF separate from its immune-regulating properties.
The major research topics of our group are: Multiple Sclerosis and demyelinating diseases of the CNS ; Experimental Autoimmune Encephalitis ; Biomarkers of the serum and the cerebrospinal fluid in MS ; Study of neuroprotective factors in EAE and MS ; Study of Human Herpes-6 variant A and B in sporadic encephalitis.

Group website

Latest publications

Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study.

Dekeyser C , Hautekeete M , Cambron M , Van Pesch V , Patti F , Kuhle J , Khoury S , Lechner Scott J , Gerlach O , Lugaresi A , Maimone D , Surcinelli A , Grammond P , Kalincik T , Habek M , Willekens B , Macdonell R , Lalive P , Csepany T , Butzkueven H , Boz C , Tomassini V , Foschi M , Sánchez-Menoyo JL , Altintas A , Mrabet S , Iuliano G , Sa MJ , Alroughani R , Karabudak R , Aguera-Morales E , Gray O , de Gans K , van der Walt A , McCombe PA , Deri N , Garber J , Al-Asmi A , Skibina O , Duquette P , Cartechini E , Spitaleri D , Gouider R , Soysal A , Van Hijfte L , Slee M , Amato MP , Buzzard K , Laureys G

Journal of neurology, neurosurgery, and psychiatry - Apr 2024

Persistence and emergence of new neuropsychological deficits following SARS-CoV-2 infection: A follow-up assessment of the Geneva COVID-COG cohort.

Voruz P , de Alcântara IJ , Nuber-Champier A , Cionca A , Guérin D , Allali G , Benzakour L , Lalive PH , Lövblad KO , Braillard O , Nencha U , Nehme M , Coen M , Serratrice J , Reny JL , Pugin J , Guessous I , Landis BN , Assal F , Péron JA

Journal of global health - Mar 2024

High-dose glucocorticoids in COVID-19 patients with acute encephalopathy: clinical and imaging findings in a retrospective cohort study.

Rhally A , Bommarito G , Uginet M , Breville G , Stancu P , Accorroni A , Assal F , Lalive PH , Lövblad KO , Allali G

Journal of neural transmission (Vienna, Austria : 1996) - Apr 2024

Complement Activation Is Associated With Disease Severity in Multiple Sclerosis.

Oechtering J , Stein K , Schaedelin SA , Maceski AM , Orleth A , Meier S , Willemse E , Qureshi F , Heijnen I , Regeniter A , Derfuss T , Benkert P , D'Souza M , Limberg M , Fischer-Barnicol B , Achtnichts L , Mueller S , Salmen A , Lalive PH , Bridel C , Pot C , Du Pasquier RA , Gobbi C , Wiendl H , Granziera C , Kappos L , Trendelenburg M , Leppert D , Lunemann JD , Kuhle J ,

Neurology(R) neuroimmunology & neuroinflammation - Mar 2024

See the complete list of the publications

Contact

Département des neurosciences cliniques
HUG
Email: Patrice.Lalive@hcuge.ch