Patrice Lalive

Function: Professeur associé

Group name: Neuroimmunology

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domains: Development and Plasticity, Sensory and Motor Systems

Keywords: biomarkers, encephalitis, multiple sclerosis, neurodegeneration, neuroprotection

Research activities

Our group is interested in both fundamental and clinically-oriented research projects in inflammatory/demyelinating diseases of the central nervous system (CNS), and in particular on the pathogenesis and regulation of Multiple Sclerosis (MS). Our major interests are (i) the search for new biomarkers for MS inflammation and neurodegeneration and (ii) the identification of the mechanisms of action of current MS therapies.
Because of its many similarities to MS, experimental autoimmune encephalitis (EAE), the animal model of MS, is regularly used in our laboratory to study MS pathogenesis and regulation. We are currently developing new animal models to study the neuroprotective effects of HGF separate from its immune-regulating properties.
The major research topics of our group are: Multiple Sclerosis and demyelinating diseases of the CNS ; Experimental Autoimmune Encephalitis ; Biomarkers of the serum and the cerebrospinal fluid in MS ; Study of neuroprotective factors in EAE and MS ; Study of Human Herpes-6 variant A and B in sporadic encephalitis.

Group website

Latest publications

MultiSCRIPT-Cycle 1-a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial.

Janiaud P , Zecca C , Salmen A , Benkert P , Schädelin S , Orleth A , Demuth L , Maceski AM , Granziera C , Oechtering J , Leppert D , Derfuss T , Achtnichts L , Findling O , Roth P , Lalive P , Uginet M , Müller S , Pot C , Hoepner R , Disanto G , Gobbi C , Rooshenas L , Schwenkglenks M , Lambiris MJ , Kappos L , Kuhle J , Yaldizli Ö , Hemkens LG

Trials - Sep 2024

Contrast-Enhancing Lesion Segmentation in Multiple Sclerosis: A Deep Learning Approach Validated in a Multicentric Cohort.

Greselin M , Lu PJ , Melie-Garcia L , Ocampo-Pineda M , Galbusera R , Cagol A , Weigel M , de Oliveira Siebenborn N , Ruberte E , Benkert P , Müller S , Finkener S , Vehoff J , Disanto G , Findling O , Chan A , Salmen A , Pot C , Bridel C , Zecca C , Derfuss T , Lieb JM , Diepers M , Wagner F , Vargas MI , Pasquier RD , Lalive PH , Pravatà E , Weber J , Gobbi C , Leppert D , Kim OC , Cattin PC , Hoepner R , Roth P , Kappos L , Kuhle J , Granziera C

Bioengineering (Basel, Switzerland) - Aug 2024

Machine-learning-based prediction of disability progression in multiple sclerosis: An observational, international, multi-center study.

De Brouwer E , Becker T , Werthen-Brabants L , Dewulf P , Iliadis D , Dekeyser C , Laureys G , Van Wijmeersch B , Popescu V , Dhaene T , Deschrijver D , Waegeman W , De Baets B , Stock M , Horakova D , Patti F , Izquierdo G , Eichau S , Girard M , Prat A , Lugaresi A , Grammond P , Kalincik T , Alroughani R , Grand'Maison F , Skibina O , Terzi M , Lechner-Scott J , Gerlach O , Khoury SJ , Cartechini E , Van Pesch V , Sà MJ , Weinstock-Guttman B , Blanco Y , Ampapa R , Spitaleri D , Solaro C , Maimone D , Soysal A , Iuliano G , Gouider R , Castillo-Triviño T , Sánchez-Menoyo JL , Laureys G , van der Walt A , Oh J , Aguera-Morales E , Altintas A , Al-Asmi A , de Gans K , Fragoso Y , Csepany T , Hodgkinson S , Deri N , Al-Harbi T , Taylor B , Gray O , Lalive P , Rozsa C , McGuigan C , Kermode A , Sempere AP , Mihaela S , Simo M , Hardy T , Decoo D , Hughes S , Grigoriadis N , Sas A , Vella N , Moreau Y , Peeters L

PLOS digital health - Jul 2024

Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study.

Dekeyser C , Hautekeete M , Cambron M , Van Pesch V , Patti F , Kuhle J , Khoury S , Lechner Scott J , Gerlach O , Lugaresi A , Maimone D , Surcinelli A , Grammond P , Kalincik T , Habek M , Willekens B , Macdonell R , Lalive P , Csepany T , Butzkueven H , Boz C , Tomassini V , Foschi M , Sánchez-Menoyo JL , Altintas A , Mrabet S , Iuliano G , Sa MJ , Alroughani R , Karabudak R , Aguera-Morales E , Gray O , de Gans K , van der Walt A , McCombe PA , Deri N , Garber J , Al-Asmi A , Skibina O , Duquette P , Cartechini E , Spitaleri D , Gouider R , Soysal A , Van Hijfte L , Slee M , Amato MP , Buzzard K , Laureys G

Journal of neurology, neurosurgery, and psychiatry - Apr 2024

See the complete list of the publications

Contact

Département des neurosciences cliniques
HUG
Email: Patrice.Lalive@hcuge.ch