Patrice Lalive

Function: Professeur associé

Group name: Neuroimmunology

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domains: Development and Plasticity, Sensory and Motor Systems

Keywords: biomarkers, encephalitis, multiple sclerosis, neurodegeneration, neuroprotection

Research activities

Our group is interested in both fundamental and clinically-oriented research projects in inflammatory/demyelinating diseases of the central nervous system (CNS), and in particular on the pathogenesis and regulation of Multiple Sclerosis (MS). Our major interests are (i) the search for new biomarkers for MS inflammation and neurodegeneration and (ii) the identification of the mechanisms of action of current MS therapies.
Because of its many similarities to MS, experimental autoimmune encephalitis (EAE), the animal model of MS, is regularly used in our laboratory to study MS pathogenesis and regulation. We are currently developing new animal models to study the neuroprotective effects of HGF separate from its immune-regulating properties.
The major research topics of our group are: Multiple Sclerosis and demyelinating diseases of the CNS ; Experimental Autoimmune Encephalitis ; Biomarkers of the serum and the cerebrospinal fluid in MS ; Study of neuroprotective factors in EAE and MS ; Study of Human Herpes-6 variant A and B in sporadic encephalitis.

Latest publications

Comparative effectiveness of teriflunomide and ocrelizumab on smoldering activity in multiple sclerosis: an observational study in the Swiss Multiple Sclerosis Cohort.

Cagol A , Schaedelin S , Ocampo-Pineda M , Benkert P , Melie-Garcia L , Luchetti L , Yaldizli Ö , Oechtering J , D'Souza M , Fischer-Barnicol B , Müller S , Finkener S , Vehoff J , Disanto G , Chan A , Pot C , Zecca C , Derfuss T , Lieb JM , Diepers M , Wagner F , Du Pasquier R , Lalive PH , Pravatà E , Kim OC , Hoepner R , Roth P , Gobbi C , Leppert D , Battaglini M , Kappos L , Sormani MP , Kuhle J , Granziera C ,

Journal of neurology - Jul 2025

Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study.

Yaldizli Ö , Benkert P , Achtnichts L , Bar-Or A , Bohner-Lang V , Bridel C , Comabella M , Findling O , Disanto G , Finkener S , Gobbi C , Granziera C , Herwerth M , Hoepner R , Horakova D , Kamber N , Khalil M , Kunz P , Lalive P , Linker R , Lorscheider J , Müller S , Oechtering J , Pettypool V , Piehl F , Pot C , Roth P , Théaudin M , Tintore M , Tur C , Uffer D , Uginet M , Vehoff J , Wiendl H , Ziemssen T , Zecca C , Salmen A , Leppert D , Derfuss T , Kappos L , Hemkens LG , Janiaud P , Kuhle J

Multiple sclerosis (Houndmills, Basingstoke, England) - Apr 2025

Standardized Definition of Progression Independent of Relapse Activity (PIRA) in Relapsing-Remitting Multiple Sclerosis.

Müller J , Sharmin S , Lorscheider J , Ozakbas S , Karabudak R , Horakova D , Weinstock-Guttman B , Shaygannejad V , Etemadifar M , Alroughani R , Patti F , Eichau S , Prat A , Lugaresi A , Tomassini V , Kermode AG , Amato MP , Turkoglu R , Altintas A , Buzzard K , Soysal A , van der Walt A , Butzkueven H , Blanco Y , Gerlach O , Khoury SJ , Barnett M , John N , Lechner-Scott J , Foschi M , Surcinelli A , van Pesch V , Prevost J , Sa MJ , Maimone D , D'hooghe M , Hughes S , Hodgkinson S , McGuigan C , Cartechini E , Taylor B , Spitaleri D , Slee M , McCombe P , Yamout B , Benkert P , Kuhle J , Kappos L , Roos I , Kalincik T , , Havrdova EK , Girard M , Duquette P , Fabis-Pedrini M , Carroll WM , Skibina O , Gouider R , Mrabet S , Ramo-Tello C , Solaro C , Habek M , Van Wijmeersch B , Ampapa R , Macdonell R , Oreja-Guevara C , de Gans K , Laureys G , Oh J , Garber J , Gray O , Agüera-Morales E , Sanchez-Menoyo JL , Castillo-Triviño T , Grigoriadis N , Petersen T , Hardy TA , Vucic S , Reddel S , Ramanathan S , Al-Asmi A , Simu M , Baghbanian SM , Poehlau D , Al-Harbi T , Rojas JI , Deri N , Lalive P , Cambron M , Csepany T , Shuey N , Willekens B , Shaw C , Decoo D , Massey J , Yaldizli Ö , Derfuss T , Granziera C

JAMA neurology - Jun 2025

Explainable time-to-progression predictions in multiple sclerosis.

D'hondt R , Dedja K , Aerts S , Van Wijmeersch B , Kalincik T , Reddel S , Havrdova EK , Lugaresi A , Weinstock-Guttman B , Mrabet S , Lalive P , Kermode AG , Ozakbas S , Patti F , Prat A , Tomassini V , Roos I , Alroughani R , Gerlach O , Khoury SJ , van Pesch V , Sá MJ , Prevost J , Spitaleri D , McCombe P , Solaro C , van der Walt A , Butzkueven H , Laureys G , Sánchez-Menoyo JL , de Gans K , Al-Asmi A , Deri N , Csepany T , Al-Harbi T , Carroll WM , Rozsa C , Singhal B , Hardy TA , Ramanathan S , Peeters L , Vens C ,

Computer methods and programs in biomedicine - May 2025

See the complete list of the publications

Contact

Département des neurosciences cliniques
HUG
Email: Patrice.Lalive@hcuge.ch