Geneva University Neurocenter
Patrice Lalive

Patrice Lalive

Function: Professeur associé

Group name: Neuroimmunology

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domains: Development and Plasticity, Sensory and Motor Systems

Keywords: biomarkers, encephalitis, multiple sclerosis, neurodegeneration, neuroprotection

Research activities

Our group is interested in both fundamental and clinically-oriented research projects in inflammatory/demyelinating diseases of the central nervous system (CNS), and in particular on the pathogenesis and regulation of Multiple Sclerosis (MS). Our major interests are (i) the search for new biomarkers for MS inflammation and neurodegeneration and (ii) the identification of the mechanisms of action of current MS therapies.
Because of its many similarities to MS, experimental autoimmune encephalitis (EAE), the animal model of MS, is regularly used in our laboratory to study MS pathogenesis and regulation. We are currently developing new animal models to study the neuroprotective effects of HGF separate from its immune-regulating properties.
The major research topics of our group are: Multiple Sclerosis and demyelinating diseases of the CNS ; Experimental Autoimmune Encephalitis ; Biomarkers of the serum and the cerebrospinal fluid in MS ; Study of neuroprotective factors in EAE and MS ; Study of Human Herpes-6 variant A and B in sporadic encephalitis.

 Group website

 

Latest publications

The risk of secondary progressive multiple sclerosis is geographically determined but modifiable.

Sharmin S , Roos I , Simpson-Yap S , Malpas C , Sánchez MM , Ozakbas S , Horakova D , Havrdova EK , Patti F , Alroughani R , Izquierdo G , Eichau S , Boz C , Zakaria M , Onofrj M , Lugaresi A , Weinstock-Guttman B , Prat A , Girard M , Duquette P , Terzi M , Amato MP , Karabudak R , Grand'Maison F , Khoury SJ , Grammond P , Lechner-Scott J , Buzzard K , Skibina O , van der Walt A , Butzkueven H , Turkoglu R , Altintas A , Maimone D , Kermode A , Shalaby N , Pesch VV , Butler E , Sidhom Y , Gouider R , Mrabet S , Gerlach O , Soysal A , Barnett M , Kuhle J , Hughes S , Sa MJ , Hodgkinson S , Oreja-Guevara C , Ampapa R , Petersen T , Ramo-Tello C , Spitaleri D , McCombe P , Taylor B , Prevost J , Foschi M , Slee M , McGuigan C , Laureys G , Hijfte LV , de Gans K , Solaro C , Oh J , Macdonell R , Aguera-Morales E , Singhal B , Gray O , Garber J , Wijmeersch BV , Simu M , Triviño TC , Sanchez-Menoyo JL , Khurana D , Al-Asmi A , Al-Harbi T , Deri N , Fragoso Y , Lalive PH , Sinnige LGF , Shaw C , Shuey N , Csepany T , Sempere AP , Moore F , Decoo D , Willekens B , Gobbi C , Massey J , Hardy T , Parratt J , Kalincik T
Brain : a journal of neurology - Jun 2023

A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients.

Todea AR , Melie-Garcia L , Barakovic M , Cagol A , Rahmanzadeh R , Galbusera R , Lu PJ , Weigel M , Ruberte E , Radue EW , Schaedelin S , Benkert P , Oezguer Y , Sinnecker T , Müller S , Achtnichts L , Vehoff J , Disanto G , Findling O , Chan A , Salmen A , Pot C , Lalive P , Bridel C , Zecca C , Derfuss T , Remonda L , Wagner F , Vargas M , Du Pasquier R , Pravata E , Weber J , Gobbi C , Leppert D , Wuerfel J , Kober T , Marechal B , Corredor-Jerez R , Psychogios M , Lieb J , Kappos L , Cuadra MB , Kuhle J , Granziera C ,
Journal of magnetic resonance imaging : JMRI - Sep 2023
See the complete list of the publications

Contact

Département des neurosciences cliniques
HUG
Email: Patrice.Lalive@hcuge.ch