Patrice Lalive

Patrice Lalive

Function: Professeur associé

Group name: Neuroimmunology

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domains: Development and Plasticity, Sensory and Motor Systems

Keywords: biomarkers, encephalitis, multiple sclerosis, neurodegeneration, neuroprotection

Research activities

Our group is interested in both fundamental and clinically-oriented research projects in inflammatory/demyelinating diseases of the central nervous system (CNS), and in particular on the pathogenesis and regulation of Multiple Sclerosis (MS). Our major interests are (i) the search for new biomarkers for MS inflammation and neurodegeneration and (ii) the identification of the mechanisms of action of current MS therapies.
Because of its many similarities to MS, experimental autoimmune encephalitis (EAE), the animal model of MS, is regularly used in our laboratory to study MS pathogenesis and regulation. We are currently developing new animal models to study the neuroprotective effects of HGF separate from its immune-regulating properties.
The major research topics of our group are: Multiple Sclerosis and demyelinating diseases of the CNS ; Experimental Autoimmune Encephalitis ; Biomarkers of the serum and the cerebrospinal fluid in MS ; Study of neuroprotective factors in EAE and MS ; Study of Human Herpes-6 variant A and B in sporadic encephalitis.

 Group website

 

Latest publications

Complement Activation Is Associated With Disease Severity in Multiple Sclerosis.

Oechtering J , Stein K , Schaedelin SA , Maceski AM , Orleth A , Meier S , Willemse E , Qureshi F , Heijnen I , Regeniter A , Derfuss T , Benkert P , D'Souza M , Limberg M , Fischer-Barnicol B , Achtnichts L , Mueller S , Salmen A , Lalive PH , Bridel C , Pot C , Du Pasquier RA , Gobbi C , Wiendl H , Granziera C , Kappos L , Trendelenburg M , Leppert D , Luenemann JD , Kuhle J ,
Neurology(R) neuroimmunology & neuroinflammation - Mar 2024

Predictors of treatment switching in the Big Multiple Sclerosis Data Network.

Spelman T , Magyari M , Butzkueven H , Van Der Walt A , Vukusic S , Trojano M , Iaffaldano P , Horáková D , Drahota J , Pellegrini F , Hyde R , Duquette P , Lechner-Scott J , Sajedi SA , Lalive P , Shaygannejad V , Ozakbas S , Eichau S , Alroughani R , Terzi M , Girard M , Kalincik T , Grand'Maison F , Skibina O , Khoury SJ , Yamout B , Sa MJ , Gerlach O , Blanco Y , Karabudak R , Oreja-Guevara C , Altintas A , Hughes S , McCombe P , Ampapa R , de Gans K , McGuigan C , Soysal A , Prevost J , John N , Inshasi J , Stawiarz L , Manouchehrinia A , Forsberg L , Sellebjerg F , Glaser A , Pontieri L , Joensen H , Rasmussen PV , Sejbaek T , Poulsen MB , Christensen JR , Kant M , Stilund M , Mathiesen H , Hillert J ,
Frontiers in neurology - 2023

Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.

Cagol A , Benkert P , Melie-Garcia L , Schaedelin SA , Leber S , Tsagkas C , Barakovic M , Galbusera R , Lu PJ , Weigel M , Ruberte E , Radue EW , Yaldizli Ö , Oechtering J , Lorscheider J , D'Souza M , Fischer-Barnicol B , Müller S , Achtnichts L , Vehoff J , Disanto G , Findling O , Chan A , Salmen A , Pot C , Bridel C , Zecca C , Derfuss T , Lieb JM , Remonda L , Wagner F , Vargas MI , Du Pasquier RA , Lalive PH , Pravatà E , Weber J , Cattin PC , Absinta M , Gobbi C , Leppert D , Kappos L , Kuhle J , Granziera C
Neurology - Jan 2024
See the complete list of the publications

Contact

Département des neurosciences cliniques
HUG
Email: Patrice.Lalive@hcuge.ch