Geneva University Neurocenter
Patrice Lalive

Patrice Lalive

Function: Professeur associé

Group name: Neuroimmunology

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domains: Development and Plasticity, Sensory and Motor Systems

Keywords: biomarkers, encephalitis, multiple sclerosis, neurodegeneration, neuroprotection

Research activities

Our group is interested in both fundamental and clinically-oriented research projects in inflammatory/demyelinating diseases of the central nervous system (CNS), and in particular on the pathogenesis and regulation of Multiple Sclerosis (MS). Our major interests are (i) the search for new biomarkers for MS inflammation and neurodegeneration and (ii) the identification of the mechanisms of action of current MS therapies.
Because of its many similarities to MS, experimental autoimmune encephalitis (EAE), the animal model of MS, is regularly used in our laboratory to study MS pathogenesis and regulation. We are currently developing new animal models to study the neuroprotective effects of HGF separate from its immune-regulating properties.
The major research topics of our group are: Multiple Sclerosis and demyelinating diseases of the CNS ; Experimental Autoimmune Encephalitis ; Biomarkers of the serum and the cerebrospinal fluid in MS ; Study of neuroprotective factors in EAE and MS ; Study of Human Herpes-6 variant A and B in sporadic encephalitis.

 Group website

 

Latest publications

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age- and BMI-Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response.

Einsiedler M , Maceski AM , Sandgren S , Oechtering J , Schaedelin S , Hofer L , Zadic A , Gomez JFV , Melie-Garcia L , Cagol A , Galbusera R , Finkener S , Lalive P , Uginet M , Müller S , Pot C , Mathias A , Du Pasquier R , Hoepner R , Chan A , Disanto G , Zecca C , D'Souza M , Hemkens LG , Derfuss T , Yaldizli Ö , Roth P , Gobbi C , Brassat D , Tackenberg B , Zetterberg H , Ziemssen T , Wiendl H , Berger K , Hermesdorf M , Piehl F , Kappos L , Granziera C , Abdelhak A , Leppert D , Willemse EAJ , Benkert P , Kuhle J ,
Annals of clinical and translational neurology - Aug 2025

Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data.

Pirmani A , De Brouwer E , Arany Á , Oldenhof M , Passemiers A , Faes A , Kalincik T , Ozakbas S , Gouider R , Willekens B , Horakova D , Havrdova EK , Patti F , Prat A , Lugaresi A , Tomassini V , Grammond P , Cartechini E , Roos I , Boz C , Alroughani R , Amato MP , Buzzard K , Lechner-Scott J , Guimarães J , Solaro C , Gerlach O , Soysal A , Kuhle J , Sanchez-Menoyo JL , Spitaleri D , Csepany T , Van Wijmeersch B , Ampapa R , Prevost J , Khoury SJ , Van Pesch V , John N , Maimone D , Weinstock-Guttman B , Laureys G , McCombe P , Blanco Y , Altintas A , Al-Asmi A , Garber J , Van der Walt A , Butzkueven H , de Gans K , Rozsa C , Taylor B , Al-Harbi T , Sas A , Rajda C , Gray O , Decoo D , Carroll WM , Kermode AG , Fabis-Pedrini M , Mason D , Perez-Sempere A , Simu M , Shuey N , Singhal B , Cauchi M , Hardy TA , Ramanathan S , Lalive P , Sirbu CA , Hughes S , Castillo Trivino T , Peeters LM , Moreau Y
NPJ digital medicine - Jul 2025

Comparative effectiveness of teriflunomide and ocrelizumab on smoldering activity in multiple sclerosis: an observational study in the Swiss Multiple Sclerosis Cohort.

Cagol A , Schaedelin S , Ocampo-Pineda M , Benkert P , Melie-Garcia L , Luchetti L , Yaldizli Ö , Oechtering J , D'Souza M , Fischer-Barnicol B , Müller S , Finkener S , Vehoff J , Disanto G , Chan A , Pot C , Zecca C , Derfuss T , Lieb JM , Diepers M , Wagner F , Du Pasquier R , Lalive PH , Pravatà E , Kim OC , Hoepner R , Roth P , Gobbi C , Leppert D , Battaglini M , Kappos L , Sormani MP , Kuhle J , Granziera C ,
Journal of neurology - Jul 2025
See the complete list of the publications

Contact

Département des neurosciences cliniques
HUG
Email: Patrice.Lalive@hcuge.ch