Most of research programs developed in our group are focused on perinatal brain injury and aim at preventing brain injury associated with premature birth or intra-uterine growth retardation. We are currently developing basic research programs including :
1- Perinatal microvasculature development in vivo and changes of gene expression controlling angiogenesis in animal models replicating perinatal brain injury.
2- Vasoreactivity and intrinsic brain connectivity of the developing brain in response to the genetic modulation of oxytocin CNS secretion from ParaVentricular Nucleus and remote modulation of microglial activation within the developing white matter.
3- Effect of sensorimotor interventions in the neonatal rat on regional blood volume changes and in vivo cortical connectivity using a new functional brain imaging modality (Ultrafast Doppler).
mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
Association between Baseline Cortisol Serum Concentrations and the Effect of Prophylactic Hydrocortisone in Extremely Preterm Infants.
In-line filtration in very preterm neonates: a randomized controlled trial.
Editorial: Preventing Developmental Brain Injury-From Animal Models to Clinical Trials.
Département de pédiatrie