Function: Professeur ordinaire
Group name: Pathogenesis of perinatal brain damage and neuroprotection of the developing brain
Group type: Main
Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Paediatrics
Domains: Development and Plasticity
Keywords: angiogenesis, brain development, brain imaging, brain lesions, cortical connectivity
Most of research programs developed in our group are focused on perinatal brain injury and aim at preventing brain injury associated with premature birth or intra-uterine growth retardation. We are currently developing basic research programs including :
1- Perinatal microvasculature development in vivo and changes of gene expression controlling angiogenesis in animal models replicating perinatal brain injury.
2- Vasoreactivity and intrinsic brain connectivity of the developing brain in response to the genetic modulation of oxytocin CNS secretion from ParaVentricular Nucleus and remote modulation of microglial activation within the developing white matter.
3- Effect of sensorimotor interventions in the neonatal rat on regional blood volume changes and in vivo cortical connectivity using a new functional brain imaging modality (Ultrafast Doppler).
Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study.
Cerebral Oximetry Monitoring in Extremely Preterm Infants.
The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation.
Neurocognitive outcomes at age 5 years after prophylactic hydrocortisone in infants born extremely preterm.
Département de pédiatrie