Every year, a large number of human fetuses and infants receive anesthesia worldwide. Anesthetics interfere with GABAergic and glutamatergic neurotransmissions that play a critical role in brain development. Our major research interest is to evaluate the impact of anesthetics on the developing central nervous system (CNS). We primarily focus on neuronal dendritic development and seek to elucidate whether exposure to anesthetics induce adverse effects on neuronal differentiation during the early postnatal period. For this purpose, we use in vitro and in vivo models of dendritic differentiation as well as various morphological and functional techniques including confocal imaging, quantitative dendritic arbor analysis and laser capture microdissection.
Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons.
Transient Deregulation of Canonical Wnt Signaling in Developing Pyramidal Neurons Leads to Dendritic Defects and Impaired Behavior.
Increased Reactivity of the Mesolimbic Reward System after Ketamine Injection in Patients with Treatment-resistant Major Depressive Disorder.
Efficacy and Safety of a Rapid Intravenous Injection of Ketamine 0.5 mg/kg in Treatment-Resistant Major Depression: An Open 4-Week Longitudinal Study.
Département d’anesthésiologie, pharmacologie et soins intensifs