Every year, a large number of human fetuses and infants receive anesthesia worldwide. Anesthetics interfere with GABAergic and glutamatergic neurotransmissions that play a critical role in brain development. Our major research interest is to evaluate the impact of anesthetics on the developing central nervous system (CNS). We primarily focus on neuronal dendritic development and seek to elucidate whether exposure to anesthetics induce adverse effects on neuronal differentiation during the early postnatal period. For this purpose, we use in vitro and in vivo models of dendritic differentiation as well as various morphological and functional techniques including confocal imaging, quantitative dendritic arbor analysis and laser capture microdissection.
Efficacy and Safety of a Rapid Intravenous Injection of Ketamine 0.5 mg/kg in Treatment-Resistant Major Depression: An Open 4-Week Longitudinal Study.
When the Safe Alternative Is Not That Safe: Tramadol Prescribing in Children.
Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex.
Can We Really Suggest that Anesthesia Might Cause Attention-deficit/Hyperactivity Disorder?
Département d’anesthésiologie, pharmacologie et soins intensifs