Laszlo Vutskits
Group name: Neuroscience-oriented Anesthesia Research Group
Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Anaesthetics, Pharmacology and Intensive Care
Domains: Development and Plasticity
Keywords: anesthesia, brain development, neurotransmission
Research activities
Every year, a large number of human fetuses and infants receive anesthesia worldwide. Anesthetics interfere with GABAergic and glutamatergic neurotransmissions that play a critical role in brain development. Our major research interest is to evaluate the impact of anesthetics on the developing central nervous system (CNS). We primarily focus on neuronal dendritic development and seek to elucidate whether exposure to anesthetics induce adverse effects on neuronal differentiation during the early postnatal period. For this purpose, we use in vitro and in vivo models of dendritic differentiation as well as various morphological and functional techniques including confocal imaging, quantitative dendritic arbor analysis and laser capture microdissection.
Latest publications
Ventilation strategies and risk factors for intraoperative respiratory critical events and postoperative pulmonary complications in neonates and small infants: a secondary analysis of the NECTARINE cohort.
Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons.
Developmental Anesthesia Neurotoxicity Research in Humans: Moving the Concept.
Dexmedetomidine in paediatric anaesthesia: a call for action?
Contact
Département d’anesthésiologie, pharmacologie et soins intensifs
HUG
Email: Laszlo.Vutskits@hcuge.ch