Karl Schaller

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Group name: Geneva Neuro-glia-vascular Lab

Keywords: brain injury, glia, neuroprotection, stroke

Research activities

The main interest of our lab is to better understand the neuro-glia-vascular physiology in the normal and pathological brain. Our research focuses on the 3 most important cell types in the brain: neuron, astrocyte and endothelial cell. These cells are affected after stroke or brain trauma. Our aim is to investigate how these cells interacts using in vitro and in vivo models. This understanding is important for the development of new neuroprotective and restorative therapies. The group of Prof K. Schaller is comprised of three teams working on specific aspects of the neuro-glio-vascular unit. (Dr Bijlenga’s team, interested in intracellular calcium modifications in neurones and glia during ischemia ; Dr Badaut’s team, the role of the astrocyte in the brain water and energy homeostasis ; Dr da Silva’s team, the role of L-arginine/arginase pathway in the autocrine and paracrine regulation of the cell types present in the neuromuscular unit ; Dr Schatlo, investigating molecular mechanisms of brain damage following cerebral vasospasm following subarachnoid hemorrhage and stroke.)

Group website

Latest publications

Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study.

Fallah A , Lewis E , Ibrahim GM , Kola O , Tseng CH , Harris WB , Chen JS , Lin KM , Cai LX , Liu QZ , Lin JL , Zhou WJ , Mathern GW , Smyth MD , O'Neill BR , Dudley RWR , Ragheb J , Bhatia S , Delev D , Ramantani G , Zentner J , Wang AC , Dorfer C , Feucht M , Czech T , Bollo RJ , Issabekov G , Zhu H , Connolly M , Steinbok P , Zhang JG , Zhang K , Hidalgo ET , Weiner HL , Wong-Kisiel L , Lapalme-Remis S , Tripathi M , Sarat Chandra P , Hader W , Wang FP , Yao Y , Champagne PO , Brunette-Clément T , Guo Q , Li SC , Budke M , Pérez-Jiménez MA , Raftopoulos C , Finet P , Michel P , Schaller K , Stienen MN , Baro V , Cantillano Malone C , Pociecha J , Chamorro N , Muro VL , von Lehe M , Vieker S , Oluigbo C , Gaillard WD , Al-Khateeb M , Al Otaibi F , Krayenbühl N , Bolton J , Pearl PL , Weil AG

Epilepsia - Sep 2021

Spinal Meningiomas: Influence of Cord Compression and Radiological Features on Preoperative Functional Status and Outcome.

Baro V , Moiraghi A , Carlucci V , Paun L , Anglani M , Ermani M , Saladino A , Chioffi F , d'Avella D , Landi A , Bartoli A , DiMeco F , Schaller K , Denaro L , Tessitore E

Cancers - Aug 2021

Microsurgical treatment of symptomatic vestibular schwannomas in patients under 40: different results before and after age of 30.

Mastronardi L , Campione A , Cacciotti G , Carpineta E , Scavo CG , Roperto R , Stati G , Sufianov AA , Schaller K

Neurosurgical review - Aug 2021

Evaluation of the effect of standard neuronavigation and augmented reality on the integrity of the perifocal structures during a neurosurgical approach.

Davidovic A , Chavaz L , Meling TR , Schaller K , Bijlenga P , Haemmerli J

Neurosurgical focus - 08 2021

See the complete list of the publications

Videos

Salle de dissection et neurochirurgie

Contact

Département des neurosciences cliniques
HUG
Email: Karl.Schaller@hcuge.ch