Karl Schaller
Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences
Group name: Geneva Neuro-glia-vascular Lab
Domains: Development and Plasticity
Keywords: brain injury, glia, neuroprotection, stroke
Research activities
The main interest of our lab is to better understand the neuro-glia-vascular physiology in the normal and pathological brain. Our research focuses on the 3 most important cell types in the brain: neuron, astrocyte and endothelial cell. These cells are affected after stroke or brain trauma. Our aim is to investigate how these cells interacts using in vitro and in vivo models. This understanding is important for the development of new neuroprotective and restorative therapies. The group of Prof K. Schaller is comprised of three teams working on specific aspects of the neuro-glio-vascular unit. (Dr Bijlenga’s team, interested in intracellular calcium modifications in neurones and glia during ischemia ; Dr Badaut’s team, the role of the astrocyte in the brain water and energy homeostasis ; Dr da Silva’s team, the role of L-arginine/arginase pathway in the autocrine and paracrine regulation of the cell types present in the neuromuscular unit ; Dr Schatlo, investigating molecular mechanisms of brain damage following cerebral vasospasm following subarachnoid hemorrhage and stroke.)
Latest publications
Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2].
Current state of global neurosurgery activity amongst European neurosurgeons.
From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review.
Do neurosurgeons follow the guidelines? A world-based survey on severe traumatic brain injury.
Videos
Contact
Département des neurosciences cliniques
HUG
Email: Karl.Schaller@hcuge.ch