Our research focuses on the psychopathological, behavioral and neural processes underlying neuropsychiatric disorders (in particular, negative symptoms of schizophrenia) and their translational potential.
Our research work is organized in two axes:
- The first axis targets the neurobiological mechanisms of negative symptoms in schizophrenia by :
- combining advanced human functional and structural neuroimaging with clinical psychopathological measures
- aiming to identify reliable biomarkers in brain-wide association studies using large functional and structural datasets
- employing a translational cross-species examination approach
- The second axis aims at employing non-invasive therapeutic approaches including neuromodulation with transcranial magnetic stimulation and developing brief psychotherapeutic interventions for these extremely disabling symptoms for patients and their families.
Pathophysiology of negative symptom dimensions of schizophrenia - Current developments and implications for treatment
Indrit Bègue, Stefan Kaiser, Matthias Kirschner
Neurosci Biobehav Rev, Sep;116:74-88 (2020)
Cerebellar and cortico-striatal-midbrain contributions to reward-cognition processes and apathy within the psychosis continuum
Indrit Bègue, Janis Brakowski, Erich Seifritz, Alain Dagher, Philippe N Tobler, Matthias Kirschner, Stefan Kaiser
Schizophr Res, Aug;246:85-94 (2022)
Confidence of emotion expression recognition recruits brain regions outside the face perception network
Indrit Bègue, Maarten Vaessen, Jeremy Hofmeister, Marice Pereira, Sophie Schwartz, Patrik Vuilleumier
Soc Cogn Affect Neurosci, Jan 4;14(1):81-95 (2019)