Understanding how and why certain individuals have a greater propensity to develop addictive behaviors remains a major challenge in neuroscience. Our lab is interested in investigating the risk factors and underlying neural correlates conferring a predisposition to addictive disorders (drug and behavioral addictions) and related neuropsychiatric illnesses. More specifically, we focus on understanding the contribution and interplay of behavioral trait variables considered important in the psychopathologies of addictions – impulsivity, novelty seeking and risky-decision making – and neurochemical dysregulations of the mesocorticolimbic dopamine system to the development of addictive disorders. We use a cross-species translational approach combining behavioral testing with in vivo molecular imaging techniques in human and animal models, associated with pharmacological and genetic tools in rodents
Effect of 5-HT2A receptor antagonism on levels of D2/3 receptor occupancy and adverse behavioral side-effects induced by haloperidol: a SPECT imaging study in the rat.
Dopamine D2/3 receptor availabilities and evoked dopamine release in striatum differentially predict impulsivity and novelty preference in Roman high- and low-avoidance rats.
Deep learning-guided joint attenuation and scatter correction in multitracer neuroimaging studies.
Dynamic image denoising for voxel-wise quantification with Statistical Parametric Mapping in molecular neuroimaging.
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Prof. Nathalie Ginovart
+41 22 37 95 366
+41 22 37 95 377
Ginna Uruena Mendez
+41 22 37 95 377
Département de psychiatrie
Département des neurosciences fondamentales