Function: Professeure associée
Group name: Behavioral neuroscience and neurodegeneration
Group type: Main
Affiliations: Faculty of Science, Department of Genetics and Evolution
Domains: Sensory and Motor Systems
Keywords: circadian clock, genetics, locomotor behavior, Parkinson's disease
How does the nervous system generate and modulate behaviors? What causes abnormal behaviors? The research in our lab is aiming at answering these questions at the molecular and neuronal levels. To this end, we have been pursuing two research foci related to locomotor behavior: 1. Molecular and neural basis of circadian locomotor behavior, and 2. Mechanisms of neurodegeneration in Parkinson’s disease. We take a multidisciplinary approach combining molecular biology, high-throughput genomic techniques, genetics, behavioral assays and live-imaging. We have been using Drosophila melanogaster as a principal model system, because its small-scale nervous system and a battery of advanced genetic tools enable the interrogation of neural circuits and molecular mechanisms in vivo. For the study of Parkinsonís disease, we are now expanding our work into the research using mouse models.
The utility and caveat of split-GAL4s in the study of neurodegeneration.
Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor.
Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.
Uncovering the Roles of Clocks and Neural Transmission in the Resilience of Circadian Network.
Faculté des sciences
Université de Genève