Emi Nagoshi

Affiliations: Faculty of Science, Department of Genetics and Evolution

Group name: Behavioral neuroscience and neurodegeneration

Keywords: circadian clock, genetics, locomotor behavior, Parkinson's disease

Research activities

How does the nervous system generate and modulate behaviors? What causes abnormal behaviors? The research in our lab is aiming at answering these questions at the molecular and neuronal levels. To this end, we have been pursuing two research foci related to locomotor behavior: 1. Molecular and neural basis of circadian locomotor behavior, and 2. Mechanisms of neurodegeneration in Parkinson’s disease. We take a multidisciplinary approach combining molecular biology, high-throughput genomic techniques, genetics, behavioral assays and live-imaging. We have been using Drosophila melanogaster as a principal model system, because its small-scale nervous system and a battery of advanced genetic tools enable the interrogation of neural circuits and molecular mechanisms in vivo. For the study of Parkinsonís disease, we are now expanding our work into the research using mouse models.

Group website

Latest publications

Models of Sporadic Parkinson's Disease.

Nagoshi E

International journal of molecular sciences - Oct 2018

Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons.

Tas D , Stickley L , Miozzo F , Koch R , Loncle N , Sabado V , Gnägi B , Nagoshi E

PLoS genetics - 03 2018

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture.

Sabado V , Nagoshi E

Journal of visualized experiments : JoVE - 01 2018

Guidelines for Genome-Scale Analysis of Biological Rhythms.

Hughes ME , Abruzzi KC , Allada R , Anafi R , Arpat AB , Asher G , Baldi P , de Bekker C , Bell-Pedersen D , Blau J , Brown S , Ceriani MF , Chen Z , Chiu JC , Cox J , Crowell AM , DeBruyne JP , Dijk DJ , DiTacchio L , Doyle FJ , Duffield GE , Dunlap JC , Eckel-Mahan K , Esser KA , FitzGerald GA , Forger DB , Francey LJ , Fu YH , Gachon F , Gatfield D , de Goede P , Golden SS , Green C , Harer J , Harmer S , Haspel J , Hastings MH , Herzel H , Herzog ED , Hoffmann C , Hong C , Hughey JJ , Hurley JM , de la Iglesia HO , Johnson C , Kay SA , Koike N , Kornacker K , Kramer A , Lamia K , Leise T , Lewis SA , Li J , Li X , Liu AC , Loros JJ , Martino TA , Menet JS , Merrow M , Millar AJ , Mockler T , Naef F , Nagoshi E , Nitabach MN , Olmedo M , Nusinow DA , Ptáček LJ , Rand D , Reddy AB , Robles MS , Roenneberg T , Rosbash M , Ruben MD , Rund SSC , Sancar A , Sassone-Corsi P , Sehgal A , Sherrill-Mix S , Skene DJ , Storch KF , Takahashi JS , Ueda HR , Wang H , Weitz C , Westermark PO , Wijnen H , Xu Y , Wu G , Yoo SH , Young M , Zhang EE , Zielinski T , Hogenesch JB

Journal of biological rhythms - Oct 2017

Contact

Faculté des sciences
Université de Genève
Email: Emi.Nagoshi@unige.ch