How does the nervous system generate and modulate behaviors? What causes abnormal behaviors? The research in our lab is aiming at answering these questions at the molecular and neuronal levels. To this end, we have been pursuing two research foci related to locomotor behavior: 1. Molecular and neural basis of circadian locomotor behavior, and 2. Mechanisms of neurodegeneration in Parkinson’s disease. We take a multidisciplinary approach combining molecular biology, high-throughput genomic techniques, genetics, behavioral assays and live-imaging. We have been using Drosophila melanogaster as a principal model system, because its small-scale nervous system and a battery of advanced genetic tools enable the interrogation of neural circuits and molecular mechanisms in vivo. For the study of Parkinsonís disease, we are now expanding our work into the research using mouse models.
Decoding Drosophila circadian pacemaker circuit.
Models of Sporadic Parkinson's Disease.
Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons.
Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture.
Faculté des sciences
Université de Genève