How does the nervous system generate and modulate behaviors? What causes abnormal behaviors? The research in our lab is aiming at answering these questions at the molecular and neuronal levels. To this end, we have been pursuing two research foci related to locomotor behavior: 1. Molecular and neural basis of circadian locomotor behavior, and 2. Mechanisms of neurodegeneration in Parkinson’s disease. We take a multidisciplinary approach combining molecular biology, high-throughput genomic techniques, genetics, behavioral assays and live-imaging. We have been using Drosophila melanogaster as a principal model system, because its small-scale nervous system and a battery of advanced genetic tools enable the interrogation of neural circuits and molecular mechanisms in vivo. For the study of Parkinsonís disease, we are now expanding our work into the research using mouse models.
Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila.
The utility and caveat of split-GAL4s in the study of neurodegeneration.
Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor.
Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.
Faculté des sciences
Université de Genève