
Denis Jabaudon
Affiliations: Faculty of Medicine, Department of Basic Neurosciences
Group name: Developmental neurobiology and plasticity
Domains: Development and Plasticity
Keywords: brain development, brain networks, gene expression
Research activities
My research interests are in studying the genetic mechanisms that control cortical neuron circuit assembly during development. Specifically, work in my laboratory is aimed at identifying the gene expression programs that enable distinct subtypes of thalamic and neocortical neurons to assemble into modality-specific circuits, and understanding how sensory experience regulates these differentiation programs during development. The approaches we use to address these questions include in vivo genetic gain-and-loss of function approaches, including in utero electroporation; structural and functional analysis of transgenic mice, and electrophysiology. We have recently demonstrated functionally critical reciprocal interactions between developmental gene expression programs and circuit formation, and trust that in the long term these processes could be used to direct the recruitment of developmental mechanisms to repair abnormal or lesioned circuits.
Key publications
Temporal plasticity of apical progenitors in the developing mouse neocortex.
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.
Progenitor hyperpolarization regulates the sequential generation of neuronal subtypes in the developing neocortex.
A cross-modal genetic framework for the development and plasticity of sensory pathways.
Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons.
In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
Hide the members of the Lab

Prof. Denis Jabaudon
+41 22 37 95 387
denis.jabaudon@unige.ch

Philipp Abe
+41 22 37 94 167
philipp.abe@unige.ch

Wafae Adouan (formerly A. Dayer lab)
+41 22 37 95 359
wafae.adouan@unige.ch

Natalia Baumann
+41 22 37 95 873
natalia.baumann@unige.ch

Audrey Benoit
+41 22 37 95 171
audrey.benoit@unige.ch

Samantha Caboussat (formerly A. Dayer lab)
+41 22 37 95 888
samantha.caboussat@unige.ch

Christelle Cadilhac (formerly A. Dayer lab)
+41 22 37 95 243
christelle.cadilhac@unige.ch

Pierpaolo D'Andrea
+41 22 37 95 171
pierpaolo.dandrea@unige.ch

Pierre Fabre
+41 22 37 95 171
pierre.fabre@unige.ch

Sabine Fievre
+41 22 37 94 167
sabine.fievre@unige.ch

Laura Frangeul
+41 22 37 95 171
laura.frangeul@unige.ch

Lucia Gomez Teijeiro (formerly A. Dayer lab)
+41 22 37 95 243
lucia.gomez@unige.ch

Marisa Jaconi
+41 22 37 95 257
marisa.jaconi@unige.ch

Esther Klingler
+41 22 37 95 873
esther.klingler@unige.ch

Adrien Lavalley
+41 22 37 94 167
adrien.lavalley@unige.ch

Greta Limoni (formerly A. Dayer lab)
+41 22 37 95 241
greta.limoni@unige.ch

Quentin Lo Giudice
+41 22 37 95 873
quentin.logiudice@unige.ch

Nandkishor Mule (formerly A. Dayer lab)
+41 22 37 95 241
nandkishor.mule@unige.ch

Shingo Nakazawa
+41 22 37 95 167
shingo.nakazawa@unige.ch

Julien Prados (formerly A. Dayer lab)
+41 22 37 95 243
julien.prados@unige.ch

Sergi Roig Puiggros
+41 22 37 94 167
sergi.roigpuiggros@unige.ch

Ugo Tomasello (formerly A. Dayer lab)
+41 22 37 95 888
ugo.tomasello@unige.ch
Videos
Contact
Faculté de médecine
Université de Genève
Email: Denis.Jabaudon@unige.ch