Denis Jabaudon
Function: Professeur ordinaire
Group name: Developmental neurobiology and plasticity
Group type: Main
Affiliations: Faculty of Medicine, Department of Basic Neurosciences
Domains: Development and Plasticity
Keywords: brain development, brain networks, gene expression
Research activities
My research interests are in studying the genetic mechanisms that control cortical neuron circuit assembly during development. Specifically, work in my laboratory is aimed at identifying the gene expression programs that enable distinct subtypes of thalamic and neocortical neurons to assemble into modality-specific circuits, and understanding how sensory experience regulates these differentiation programs during development. The approaches we use to address these questions include in vivo genetic gain-and-loss of function approaches, including in utero electroporation; structural and functional analysis of transgenic mice, and electrophysiology. We have recently demonstrated functionally critical reciprocal interactions between developmental gene expression programs and circuit formation, and trust that in the long term these processes could be used to direct the recruitment of developmental mechanisms to repair abnormal or lesioned circuits.
Key publications
Temporal controls over inter-areal cortical projection neuron fate diversity.
Temporal plasticity of apical progenitors in the developing mouse neocortex.
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.
Progenitor hyperpolarization regulates the sequential generation of neuronal subtypes in the developing neocortex.
A cross-modal genetic framework for the development and plasticity of sensory pathways.
Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons.
In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
Hide the members of the Lab
Prof. Denis Jabaudon
+41 22 37 95 387
denis.jabaudon@unige.ch
Alexis Assens
+41 22 37 95 873
alexis.assens@unige.ch
Eline Balavoine
+41 22 37 95 171
eline.balavoine@unige.ch
Natalia Baumann
+41 22 37 94 167
natalia.baumann@unige.ch
Audrey Benoit
+41 22 37 95 243
audrey.benoit@unige.ch
Riccardo Bocchi
+41 22 37 95 873
riccardo.bocchi@unige.ch
Clothilde Ferreira
+41 22 37 95 171
clothilde.ferreira@unige.ch
Sabine Fievre
+41 22 37 94 167
sabine.fievre@unige.ch
Laura Frangeul
+41 22 37 95 243
laura.frangeul@unige.ch
Daniel Fuciec
+41 22 37 94 167
daniel.fuciec@unige.ch
Unai Gonzalez Manrique
unai.gonzalezmanrique@unige.ch
Marisa Jaconi
+41 22 37 95 257
marisa.jaconi@unige.ch
Awais Javed
+41 22 37 95 171
awais.javed@unige.ch
Ilaria Morassut
+41 22 37 94 167
ilaria.morassut@unige.ch
Théo Ribierre
+41 22 37 95 171
theo.ribierre@unige.ch
Sergi Roig Puiggros
+41 22 37 94 167
sergi.roigpuiggros@unige.ch
Giulia Santoni
+41 22 37 94 167
giulia.santoni@unige.ch
Moein Sarhadi
+41 22 37 94 167
moein.sarhadi@unige.ch
Timea Szalai
+41 22 37 95 171
timea.szalai@unige.ch
Jiafeng Zhou
+41 22 37 94 167
jiafeng.zhou@unige.ch
Xintao Zhu
xintao.zhu@etu.unige.ch
Contact
Faculté de médecine
Université de Genève
Email: Denis.Jabaudon@unige.ch