My research interests are in studying the genetic mechanisms that control cortical neuron circuit assembly during development. Specifically, work in my laboratory is aimed at identifying the gene expression programs that enable distinct subtypes of thalamic and neocortical neurons to assemble into modality-specific circuits, and understanding how sensory experience regulates these differentiation programs during development. The approaches we use to address these questions include in vivo genetic gain-and-loss of function approaches, including in utero electroporation; structural and functional analysis of transgenic mice, and electrophysiology. We have recently demonstrated functionally critical reciprocal interactions between developmental gene expression programs and circuit formation, and trust that in the long term these processes could be used to direct the recruitment of developmental mechanisms to repair abnormal or lesioned circuits.
Temporal plasticity of apical progenitors in the developing mouse neocortex.
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.
Progenitor hyperpolarization regulates the sequential generation of neuronal subtypes in the developing neocortex.
A cross-modal genetic framework for the development and plasticity of sensory pathways.
Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons.
In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
Faculté de médecine
Université de Genève