In the laboratory, we study the mechanisms controlling sensory perception and how different senses may interact together. How neural networks encode sensory information into the brain and how to relate behavior to neuronal activities will be of great importance for future implementation of brain-machine interfaces. We would like to precise how sensory stimuli are coded by brain networks and how these representations may be influenced by experience and across different sensory modalities. In order to address these general questions, we study chemical senses as model sensory systems. Olfactory and gustatory are probably the senses most naturally interacting together in behaving animals especially during feeding behavior. We use a multidisciplinary approach combining in vitro and in vivo electrophysiology and functional imaging, 2-photon microscopy, lentivirus gene transfer and behaviour. Among different projects, we are currently studying the network mechanisms underlying olfactory coding, the synaptic mechanisms shaping olfactory networks function and the impact of adult neurogenesis on olfaction.
Transient Deregulation of Canonical Wnt Signaling in Developing Pyramidal Neurons Leads to Dendritic Defects and Impaired Behavior.
Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia.
Evolution of immune chemoreceptors into sensors of the outside world.
Context- and Output Layer-Dependent Long-Term Ensemble Plasticity in a Sensory Circuit.
Faculté de médecine
Université de Genève