The main research interest of our group is on the neurobiology of mood disorders with a focus on the links between neuroendocrinology, stress and depression, specifically hypothalamo-hypophyso-adrenal system dysfunctions and the risk of depressive relapse. These issues are explored with pre-clinical models as well as with clinical research protocols. In collaboration with other groups in Geneva and abroad, another topic of research is addressing the mode of action of mood stabilizers with in vitro paradigms. Finally, more recently, genetic studies on unipolar and bipolar disorders have also been initiated in collaboration with other groups. Our group is now part of several international consortium evaluating the genetic basis of antidepressants and lithium response vs non-response.
Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients.
Efficacy and Safety of a Rapid Intravenous Injection of Ketamine 0.5 mg/kg in Treatment-Resistant Major Depression: An Open 4-Week Longitudinal Study.
Impulsivity and its association with childhood trauma experiences across bipolar disorder, attention deficit hyperactivity disorder and borderline personality disorder.
Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.
Département de psychiatrie