The main research interest of our group is on the neurobiology of mood disorders with a focus on the links between neuroendocrinology, stress and depression, specifically hypothalamo-hypophyso-adrenal system dysfunctions and the risk of depressive relapse. These issues are explored with pre-clinical models as well as with clinical research protocols. In collaboration with other groups in Geneva and abroad, another topic of research is addressing the mode of action of mood stabilizers with in vitro paradigms. Finally, more recently, genetic studies on unipolar and bipolar disorders have also been initiated in collaboration with other groups. Our group is now part of several international consortium evaluating the genetic basis of antidepressants and lithium response vs non-response.
Characterisation of age and polarity at onset in bipolar disorder.
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients.
Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation.
HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders.
Département de psychiatrie