Geneva University Neurocenter
Alexandre Dayer

Alexandre Dayer

Affiliations: Faculty of Medicine, Department of Basic Neurosciences

Group name: Psychiatry and developmental neuroplasticity

Domains: Development and Plasticity

Keywords: brain development, migrating neurons, psychiatric disorders

Department of Basic Neurosciences

Research activities

Neurodevelopmental abnormalities are thought to play a key role in the etiology of major psychiatric disorders such as bipolar disorder and schizophrenia. Among these developmental abnormalities, defects in the migration and differentiation of GABAergic interneurons have been suggested. In the laboratory we aim to study psychiatric-relevant molecular factors that control the migration and differentiation of cortical GABAergic interneurons during the embyronic period and the early postnatal period. For this purpose, we use mutant mice for genes implicated in cortical development as well as transgenic mice expressing GFP in cortical GABAergic interneurons. We apply a broad array of techniques including in vitro migration essays and confocal live imaging to directly monitor interneuron migration in cortical slices.

Latest publications

Prediction of lithium response using genomic data.

Stone W , Nunes A , Akiyama K , Akula N , Ardau R , Aubry JM , Backlund L , Bauer M , Bellivier F , Cervantes P , Chen HC , Chillotti C , Cruceanu C , Dayer A , Degenhardt F , Del Zompo M , Forstner AJ , Frye M , Fullerton JM , Grigoroiu-Serbanescu M , Grof P , Hashimoto R , Hou L , Jiménez E , Kato T , Kelsoe J , Kittel-Schneider S , Kuo PH , Kusumi I , Lavebratt C , Manchia M , Martinsson L , Mattheisen M , McMahon FJ , Millischer V , Mitchell PB , Nöthen MM , O'Donovan C , Ozaki N , Pisanu C , Reif A , Rietschel M , Rouleau G , Rybakowski J , Schalling M , Schofield PR , Schulze TG , Severino G , Squassina A , Veeh J , Vieta E , Trappenberg T , Alda M
Scientific reports - Jan 2021

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.

Amare AT , Schubert KO , Hou L , Clark SR , Papiol S , Cearns M , Heilbronner U , Degenhardt F , Tekola-Ayele F , Hsu YH , Shekhtman T , Adli M , Akula N , Akiyama K , Ardau R , Arias B , Aubry JM , Backlund L , Bhattacharjee AK , Bellivier F , Benabarre A , Bengesser S , Biernacka JM , Birner A , Brichant-Petitjean C , Cervantes P , Chen HC , Chillotti C , Cichon S , Cruceanu C , Czerski PM , Dalkner N , Dayer A , Del Zompo M , DePaulo JR , Étain B , Jamain S , Falkai P , Forstner AJ , Frisen L , Frye MA , Fullerton JM , Gard S , Garnham JS , Goes FS , Grigoroiu-Serbanescu M , Grof P , Hashimoto R , Hauser J , Herms S , Hoffmann P , Hofmann A , Jiménez E , Kahn JP , Kassem L , Kuo PH , Kato T , Kelsoe JR , Kittel-Schneider S , Kliwicki S , König B , Kusumi I , Laje G , Landén M , Lavebratt C , Leboyer M , Leckband SG , Tortorella A , Manchia M , Martinsson L , McCarthy MJ , McElroy SL , Colom F , Mitjans M , Mondimore FM , Monteleone P , Nievergelt CM , Nöthen MM , Novák T , O'Donovan C , Ozaki N , Ösby U , Pfennig A , Potash JB , Reif A , , Reininghaus E , Rouleau GA , Rybakowski JK , Schalling M , Schofield PR , Schweizer BW , Severino G , Shilling PD , Shimoda K , Simhandl C , Slaney CM , Squassina A , Stamm T , Stopkova P , Maj M , Turecki G , Vieta E , Veeh J , Witt SH , Wright A , Zandi PP , Mitchell PB , Bauer M , Alda M , Rietschel M , McMahon FJ , Schulze TG , Baune BT
Molecular psychiatry - Mar 2020
See the complete list of the publications

Contact

Département de psychiatrie
HUG