Neurodevelopmental abnormalities are thought to play a key role in the etiology of major psychiatric disorders such as bipolar disorder and schizophrenia. Among these developmental abnormalities, defects in the migration and differentiation of GABAergic interneurons have been suggested. In the laboratory we aim to study psychiatric-relevant molecular factors that control the migration and differentiation of cortical GABAergic interneurons during the embyronic period and the early postnatal period. For this purpose, we use mutant mice for genes implicated in cortical development as well as transgenic mice expressing GFP in cortical GABAergic interneurons. We apply a broad array of techniques including in vitro migration essays and confocal live imaging to directly monitor interneuron migration in cortical slices.
Prediction of lithium response using genomic data.
Maladaptive emotion regulation traits predict altered corticolimbic recovery from psychosocial stress.
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.
Linking alpha oscillations, attention and inhibitory control in adult ADHD with EEG neurofeedback.
Département de psychiatrie