Neurodevelopmental abnormalities are thought to play a key role in the etiology of major psychiatric disorders such as bipolar disorder and schizophrenia. Among these developmental abnormalities, defects in the migration and differentiation of GABAergic interneurons have been suggested. In the laboratory we aim to study psychiatric-relevant molecular factors that control the migration and differentiation of cortical GABAergic interneurons during the embyronic period and the early postnatal period. For this purpose, we use mutant mice for genes implicated in cortical development as well as transgenic mice expressing GFP in cortical GABAergic interneurons. We apply a broad array of techniques including in vitro migration essays and confocal live imaging to directly monitor interneuron migration in cortical slices.
Increased Reactivity of the Mesolimbic Reward System after Ketamine Injection in Patients with Treatment-resistant Major Depressive Disorder.
Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients.
Efficacy and Safety of a Rapid Intravenous Injection of Ketamine 0.5 mg/kg in Treatment-Resistant Major Depression: An Open 4-Week Longitudinal Study.
Impulsivity and its association with childhood trauma experiences across bipolar disorder, attention deficit hyperactivity disorder and borderline personality disorder.
Département de psychiatrie