Paul G Unschuld

Function: Professeur

Nom du groupe: Geriatric Mental Health and Precision Medicine

Group type: Main

Activités de recherche

A main research goal of ours is the identification of biological and environmental determinants for maintained mental health at old age. Our research is aimed at advancing individualized precision medicine interventions for treatment of aging related neurodegenerative brain disorders such as Alzheimer’s disease (AD). We are particularly interested in characterizing altered central-nervous-system function linked to progressive cognitive dysfunction, depression, anxiety, apathy and difficulties in social interaction. To this effect, a multidisciplinary, longitudinal research cohort (Geneva Geriatric Mental Health Inventory) has been established. Complex clinical assessment is combined with state of the art neuroscience methodology. This includes advanced neuroimaging studies at high magnetic field strength, innovative molecular radiopharmaceutical imaging, blood biomarker and genomic studies. Multiple ongoing research collaborations have been established with basic research groups at HUG, Campus biotech Geneva and Lausanne, ETH and University Zurich, Basel Neurology and abroad.

Group website

Publications clés

Gray matter gamma-hydroxy-butyric acid and glutamate reflect beta-amyloid burden at old age.

Schreiner SJ, Van Bergen JMG, Gietl AF, Buck A, Hock C, Pruessmann KP, Henning A, Unschuld PG.

Alzheimers Dement (Amst). 2024 Apr 30;16(2):e12587.

Polygenic risk for Alzheimer’s disease is associated with neuroaxonal damage before onset of clinical symptoms.

Kagerer SM, Awasthi S, Ripke S, Maceski A, Benkert P, Fall AB, Riederer P, Fischer P, Walitza S, Grünblatt E, Kuhle J, Unschuld PG.

Alzheimer’s Dement. 2024 Jan 9;16(1):e12504.

APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old‐aged adults

SM Kagerer, JMG van Bergen, X Li, FC Quevenco, AF Gietl, SStuder, V Treyer, R Meyer, PA Kaufmann, RM Nitsch, PCM van Zijl, C Hock, PG Unschuld.

Alzheimers Dement. 2020; 7;12(1):e12002.

Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and ß-amyloid as an indicator of cognitive performance at high age.

van Bergen JMG, Li X, Quevenco FC, Gietl AF, Treyer V, Meyer R, Buck A, Kaufmann PA, Nitsch RM, van Zijl PCM, Hock C, Unschuld PG

Neuroimage. 2018 Jul 1;174:308-316.

Colocalization of cerebral iron with amyloid beta in mild cognitive impairment.

JMG Van Bergen, X Li, J Hua, SJ Schreiner, SC Steininger, FC Quevenco, Michael Wyss, AF Gietl, V Treyer, SE Leh, F Buck, RM Nitsch, Klaas P Pruessmann, PCM Van Zijl, C Hock, PG Unschuld

Scientific reports 2016 Oct 17:6 (1), 35514

Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction.

PG Unschuld, AS Buchholz, M Varvaris, PCM Van Zijl, CA Ross, JJ Pekar, C Hock, JA Sweeney, CA Tamminga, MS Keshavan, GD Pearlson, GK Thaker, DJ Schretlen

Schizophr Bull. 2014 May; 40(3): 653–664

See the complete list of the publications

Contact

Département de Psychiatrie

Email: paul.unschuld@hcuge.ch