Activités de recherche
Most of research programs developed in our group are focused on perinatal brain injury and aim at preventing brain injury associated with premature birth or intra-uterine growth retardation. We are currently developing basic research programs including :
1- Perinatal microvasculature development in vivo and changes of gene expression controlling angiogenesis in animal models replicating perinatal brain injury.
2- Vasoreactivity and intrinsic brain connectivity of the developing brain in response to the genetic modulation of oxytocin CNS secretion from ParaVentricular Nucleus and remote modulation of microglial activation within the developing white matter.
3- Effect of sensorimotor interventions in the neonatal rat on regional blood volume changes and in vivo cortical connectivity using a new functional brain imaging modality (Ultrafast Doppler).
Survival without severe neonatal morbidity after antenatal betamethasone dose reduction: a post-hoc analysis of a randomized non-inferiority trial.
Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury.
Synergistic effect of sildenafil combined with controlled hypothermia to alleviate microglial activation after neonatal hypoxia-ischemia in rats.
Risk Factors for Dehiscence of Operative Incisions in Newborns after Laparotomy.
Département de pédiatrie