Karl Schaller

Function: Professeur ordinaire

Nom du groupe: Geneva Neuro-glia-vascular Lab

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Clinical Neurosciences

Domaines: Development and Plasticity

Mot clés: brain injury, glia, neuroprotection, stroke

Activités de recherche

The main interest of our lab is to better understand the neuro-glia-vascular physiology in the normal and pathological brain. Our research focuses on the 3 most important cell types in the brain: neuron, astrocyte and endothelial cell. These cells are affected after stroke or brain trauma. Our aim is to investigate how these cells interacts using in vitro and in vivo models. This understanding is important for the development of new neuroprotective and restorative therapies. The group of Prof K. Schaller is comprised of three teams working on specific aspects of the neuro-glio-vascular unit. (Dr Bijlenga’s team, interested in intracellular calcium modifications in neurones and glia during ischemia ; Dr Badaut’s team, the role of the astrocyte in the brain water and energy homeostasis ; Dr da Silva’s team, the role of L-arginine/arginase pathway in the autocrine and paracrine regulation of the cell types present in the neuromuscular unit ; Dr Schatlo, investigating molecular mechanisms of brain damage following cerebral vasospasm following subarachnoid hemorrhage and stroke.)

Dernières publications

Single-cell atlas of the human brain vasculature across development, adulthood and disease.

Wälchli T , Ghobrial M , Schwab M , Takada S , Zhong H , Suntharalingham S , Vetiska S , Gonzalez DR , Wu R , Rehrauer H , Dinesh A , Yu K , Chen ELY , Bisschop J , Farnhammer F , Mansur A , Kalucka J , Tirosh I , Regli L , Schaller K , Frei K , Ketela T , Bernstein M , Kongkham P , Carmeliet P , Valiante T , Dirks PB , Suva ML , Zadeh G , Tabar V , Schlapbach R , Jackson HW , De Bock K , Fish JE , Monnier PP , Bader GD , Radovanovic I

Nature - Jul 2024

Hand Dystonia after Focused Ultrasound Thalamotomy in Essential Tremor.

Cuony J , Lorton O , Tomkova Chaoui E , Comet C , Schaller K , Salomir R , Momjian S , Fleury V

Stereotactic and functional neurosurgery - Jun 2024

Simulation to become a better neurosurgeon. An international prospective controlled trial: The Passion study.

Fanizzi C , Carone G , Rocca A , Ayadi R , Petrenko V , Casali C , Rani M , Giachino M , Falsitta LV , Gambatesa E , Galbiati TF , Orena EF , Tramacere I , Riker NI , Mocca A , , Schaller K , Meling TR , DiMeco F , Perin A

Brain & spine - 2024

Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial.

Beck J , Fung C , Strbian D , Bütikofer L , Z'Graggen WJ , Lang MF , Beyeler S , Gralla J , Ringel F , Schaller K , Plesnila N , Arnold M , Hacke W , Jüni P , Mendelow AD , Stapf C , Al-Shahi Salman R , Bressan J , Lerch S , Hakim A , Martinez-Majander N , Piippo-Karjalainen A , Vajkoczy P , Wolf S , Schubert GA , Höllig A , Veldeman M , Roelz R , Gruber A , Rauch P , Mielke D , Rohde V , Kerz T , Uhl E , Thanasi E , Huttner HB , Kallmünzer B , Jaap Kappelle L , Deinsberger W , Roth C , Lemmens R , Leppert J , Sanmillan JL , Coutinho JM , Hackenberg KAM , Reimann G , Mazighi M , Bassetti CLA , Mattle HP , Raabe A , Fischer U ,

Lancet (London, England) - Jun 2024

See the complete list of the publications

Videos

Salle de dissection et neurochirurgie

Contact

Département des neurosciences cliniques
HUG
Email: Karl.Schaller@hcuge.ch