Armand Savioz

Function: Privat docent

Nom du groupe: NEURAD

Group type: Main

Affiliations: Faculty of Medicine, Geneva University Hospitals, Department of Psychiatry

Mot clés: Alzheimer's disease, degenerative dementia, synapse

Activités de recherche

Our studies deal with molecular mechanisms (e.g. synaptic beta-amyloid hypothesis) involved in vulnerability of neural networks in aging as well as in degenerative dementia (Alzheimer disease and frontotemporal dementia). Starting from observations made in humans, cellular and murine models are used to investigate how synaptic modifications and loss lead to functional alterations according to a synapto-connectionist paradigm, but may be counteracted by cerebral reserve and compensatory mechanisms.

Dernières publications

Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease.

Ceyzériat K , Badina AM , Petrelli F , Montessuit S , Nicolaides A , Millet P , Savioz A , Martinou JC , Tournier BB

Neurobiology of disease - Oct 2024

Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models.

Authiat MM , Gruz-Gibelli E , Colas J , Bianchi E , Garcia-Arauzo M , Marin P , Herrmann FR , Savioz A

Neural plasticity - 2022

Neuroprotection against Amyloid--Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways.

Colas J , Chessel N , Ouared A , Gruz-Gibelli E , Marin P , Herrmann FR , Savioz A

Neural plasticity - 2020

TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer's disease.

Tournier BB , Tsartsalis S , Rigaud D , Fossey C , Cailly T , Fabis F , Pham T , Grégoire MC , Kövari E , Moulin-Sallanon M , Savioz A , Millet P

Neurobiology of disease - Jan 2019

See the complete list of the publications

Contact

Département de psychiatrie
HUG
Email: Armand.Savioz@hcuge.ch