Anthony Holtmaat

Anthony Holtmaat

Function: Professeur ordinaire

Nom du groupe: Structural synaptic plasticity

Group type: Main

Affiliations: Faculty of Medicine, Department of Basic Neurosciences

Domaines: Sensory and Motor Systems, Development and Plasticity

Mot clés: brain networks, cranial window implants, synapse, synaptic plasticity

Activités de recherche

Our laboratory is interested in structural and morphological aspects of synaptic plasticity in the adult brain. We are testing the hypothesis that changes in the connectivity between neurons, through synapse formation and elimination, constitute a basis for training and experience-dependent adaptations in cortical network function. To this end we image cortical neurons in fluorescent transgenic mice in vivo and are able to track individual dendritic spines and axonal boutons over weeks while the animal receives new sensory experiences or loses sensory inputs. In addition we measure the molecular stability and dynamics of individual synapses by following the transport and diffusion of synaptic proteins carrying a fluorescent tag. Together these studies will deepen our understanding of how the nervous system is able to, on one hand maintain its synaptic network, and on the other hand subtly change its connectivity, in order to accommodate the animal’s memory storage as well as its ability to continuously adapt to an ever-changing environment.

Dernières publications

See the complete list of the publications

Hide the members of the Lab

Prof. Anthony Holtmaat

Group leader

CMU - C08.1541.A
+41 22 37 95 428

Tanika Bawa

Graduate student

CMU - E08.2650.A
+41 22 37 95 445

Ronan Chereau


CMU - D08.1953.A
+41 22 37 95 469

Céline Dürst

Scientific collaborator

CMU - E08.2452.A
+41 22 37 95 469

Elodie Husi

Lab technician

CMU - E08.2650.A
+41 22 37 95 445

Kok Sin Lee


CMU - E08.2650.A
+41 22 37 95 445

Foivos Markopoulos

Scientific collaborator

CMU - C08.1536.A
+41 22 37 95 355


Faculté de médecine
Université de Genève