Activités de recherche
The group’s research focus is on the negative symptoms of schizophrenia and other severe mental disorders. Negative symptoms include apathy (a reduction of motivation) and diminished expression. These symptoms have a strong negative impact on everyday functioning, while the options for treatment remain very limited.
The first research objective is to arrive at a better understanding of the motivational and cognitive processes causing these symptoms. For this goal, we use behavioral experiments and functional magnetic resonance imaging. An important line of research concerns dysfunctions of the reward system that are studied with experiments adapted from fundamental neuroscience. We emphasize the combination of these approaches with the development of instruments for clinical psychopathology aiming at better measurement of negative symptoms.
Improved understanding of negative symptoms is used for developing treatment options for negative symptoms based on the modulation of the underlying processes with psychotherapeutic and biological approaches, for example transcranial magnetic stimulation. We are also use meta-analytic methods to investigate the effects of existing treatments on negative symptoms.
Cerebellar and cortico-striatal-midbrain contributions to reward-cognition processes and apathy within the psychosis continuum.
Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum.
How far to go in deconstructing negative symptoms? Behavioural and neural level evidence for the amotivation domain.
Cannabis, nicotine and the negative symptoms of schizophrenia: Systematic review and meta-analysis of observational studies.
Deficits in context-dependent adaptive coding in early psychosis and healthy individuals with schizotypal personality traits.
Département de Psychiatrie