Activités de recherche
Our group is interested in the organization, at a molecular level, of vertebrate neuronal systems involved in the perception of the outside world. We are particularly interested in the vomeronasal (VNO) system, a system responsible for the perception of pheromones in mammals. The VNO plays a crucial role in peer-mediated neuroendocrine effects and instinctive behaviors. These include, for example, mating, the establishment of social hierarchy and the regulation of ovulation. Hundreds of specialized receptors are expressed by vomeronasal sensory neurons; these receptors appear to both play a role in chemodetection and in the establishment of a functional vomeronasal axonal projection map in the brain. Using mouse genetics, we take advantage of the remarkably regulated expression of the genes coding for these receptors (one unique gene from a single parental allele expressed per neuron), and use this very unusual particularity as a genetic door to the exploration of the system.
Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.
Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.
Control of the Two-photon Visual Process in ex vivo Retinas and in Living Mice.
Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.
Faculté des Sciences
Université de Genève