Charles Quairiaux
Function: Chargé d'Enseignement Privat-Docent
Nom du groupe: Large-scale brain networks (LSBN)
Group type: Main
Affiliations: Department of Basic Neurosciences
Domaines: Development and Plasticity
Activités de recherche
Our lab investigates large-scale brain network mechanisms and dysfunctions using in vivo electrophysiology combined with behavioural studies in rodent models. We are particularly interested in the network-level organization of focal epilepsies, the most common form being temporal lobe epilepsy (TLE). The diversity and complexity of TLE symptoms, together with high rates of drug resistance and the limited efficacy of surgical resection in some patients, suggest the need to move beyond a strict focus on a fixed hippocampal epileptic focus during chronic stages. We therefore adopt a large-scale network perspective across the different stages of the disease to better understand how epileptic activity and its cognitive consequences emerge and evolve over time, from epileptogenesis to the chronic phase. Our research is structured around two main axes. First, we address complementary questions related to the emergence of epileptic activity: can large-scale recordings improve prediction of seizures and their impact on brain function? Can targeted modulation of neuronal activity alleviate epileptic symptoms and comorbidities? What mechanisms drive epileptogenesis at both focal and network levels? Second, we investigate how epileptic networks affect memory and collaborate with clinicians to predict the cognitive outcomes of surgical interventions.
Dernières publications
Parvalbumin interneurons: the dark and bright sides of a key playmaker of neural circuits and behavior.
Involvement of the contralateral hippocampus in ictal-like but not interictal epileptic activities in the kainate mouse model of temporal lobe epilepsy.
Reproducible network changes occur in a mouse model of temporal lobe epilepsy but do not correlate with disease severity.
Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency.
Contact
Faculté de médecine
Université de Genève
Email: Charles.Quairiaux@unige.ch