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X-WR-CALNAME:Geneva University Neurocenter
X-ORIGINAL-URL:https://neurocenter-unige.ch
X-WR-CALDESC:Events for Geneva University Neurocenter
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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DTSTART;TZID=Europe/Paris:20230829T121500
DTEND;TZID=Europe/Paris:20230829T131500
DTSTAMP:20260414T073624
CREATED:20230822T193901Z
LAST-MODIFIED:20230829T005434Z
UID:18728-1693311300-1693314900@neurocenter-unige.ch
SUMMARY:B&C Tuesday Seminar "Sleep deprivation and the human brain: from brain physiology to cognition"
DESCRIPTION:Abstract : Sleep strongly affects synaptic strength\, making it critical for cognition\, especially learning and memory formation. Whether and how sleep deprivation modulates human brain physiology and cognition is poorly understood. Here we examined how overnight sleep deprivation vs overnight sufficient sleep affects (a) cortical excitability\, measured by transcranial magnetic stimulation\, (b) inducibility of long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity via transcranial direct current stimulation (tDCS)\, and (c) learning\, memory\, and attention. We found that sleep deprivation increases cortical excitability due to enhanced glutamate-related cortical facilitation and decreases and/or reverses GABAergic cortical inhibition. Furthermore\, tDCS-induced LTP-like plasticity (anodal) abolishes while the inhibitory LTD-like plasticity (cathodal) converts to excitatory LTP-like plasticity under sleep deprivation. This is associated with increased EEG theta oscillations due to sleep pressure. Motor learning\, behavioral counterparts of plasticity\, and working memory and attention\, which rely on cortical excitability\, are also impaired during sleep deprivation. Our study indicates that upscaled brain excitability and altered plasticity\, due to sleep deprivation\, are associated with impaired cognitive performance. Besides showing how brain physiology and cognition undergo changes (from neurophysiology to higher-order cognition) under sleep pressure\, the findings have implications for variability and optimal application of noninvasive brain stimulation.”
URL:https://neurocenter-unige.ch/agenda/bc-tuesday-seminar-sleep-deprivation-and-the-human-brain-from-brain-physiology-to-cognition/
LOCATION:Room H8-01-D & Zoom
CATEGORIES:Seminars brain&cognition,Seminars neurobiology
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